| 【Name】 | Brand Name: Ze LangCommon Name: Bivalirudin for InjectionEnglish Name: Bivalirudin for InjectionChinese Pinyin: Zhusheyong Bifaluding |
|---|---|
| 【Ingredient】 | The main ingredient of this product is bivalirudin.Chemical Name: D-phenylalanyl-L-prolyl-L-arginyl-L-prolyl-glycyl-glycyl-glycyl-glycyl-L-asparagyl-glycyl-L-aspartyl-L-phenylalanyl-L-glutamyl-L-glutamyl-L-isoleucyl-L-prolyl-L-glutamyl-L-glutamyl-L-tyrosyl-L-leucineChemical Structure
Molecular Formula: C98H138N24O33 Molecular Weight: 2180.28 |
| 【Description】 | This product is white loose or amorphous solid, extremely hygroscopic |
| 【Indication】 | It is indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI) |
| 【Strength】 | 0.25g（C98H138N24O33） |
| 【Dosage and Administration】 | This product is used for intravenous injection and intravenous infusion.The recommended dose of Bivalirudin is an intravenous bolus dose of 0.75 mg/kg before PCI, followed immediately by an infusion of 1.75 mg/kg/h for the duration of the PCI procedure (not more than 4 hours). Five minutes after the bolus dose has been administered, an activated clotting time (ACT) should be performed and an additional bolus of 0.3 mg/kg should be given if needed. After 4 hours, an additional IV infusion of Bivalirudin may be initiated at a rate 0.2 mg/kg/h (low-rate infusion), for up to 20 hours, if needed. Glycoprotein IIb/IIIa inhibitor (GPI) should be considered in the event that any of the conditions listed in the Replace-2 clinical trial (see Clinical Trials) is present. For patients with HIT/HITTS undergoing PCI, the recommended dose of Bivalirudin is an IV bolus of 0.75 mg/kg. This should be followed by a continuous intravenous infusion at a rate of 1.75 mg/kg/h for the duration of PCI procedure. Bivalirudin is recommended for use with aspirin (300-325 mg per day). |
